Too little and too much: medial prefrontal functional inhibition impairs early, whereas neural disinhibition impairs serial reversal performance in rats
Jacco G. Renström, C Taylor, Rachel Grasmeder Allen, Luke O’Hara, Joanna Loayza, Jacob Juty, Paula M. Moran, Moritz von Heimendahl, Serena Deiana, Johann Du Hoffman, Carl W. Stevenson, Silvia Maggi, Tobias Bast
This study investigates how medial prefrontal cortex (mPFC) hypoactivation and disinhibition affect reversal learning in rats, finding distinct impairments in early and serial reversals.
bioRxiv · Feb 10, 2025 · PreprintNeuroscience