Maintaining maximal metabolic flux by gene expression control
Robert Planqué, Josephus Hulshof, Bas Teusink, Johannes C. Hendriks, Frank J. Bruggeman
The paper develops a theoretical framework for optimal metabolic flux maintenance through gene expression control in bacteria, showing that it requires a minimum number of metabolite-regulated transcription factors.
PLoS Computational Biology · Sep 20, 2018Peer-reviewedSystems Biology