Josephus Hulshof

Sensing cellular growth rate facilitates its robust optimal adaptation to changing conditions

The paper shows that cells can sense their growth rate and optimize it through gene regulatory circuits, supported by analysis of E. coli's use of ppGpp.

Elementary Growth Modes provide a molecular description of cellular self-fabrication

The paper develops a theory to describe all possible molecular states of cellular self-fabrication, identifying Elementary Growth Modes as the fundamental building blocks of cellular phenotype.

Stability of an adaptively controlled pathway maximising specific flux under varying conditions

The paper analyzes the stability of a metabolic pathway under qORAC control, showing it achieves a unique and stable steady state with maximal flux.

Maintaining maximal metabolic flux by gene expression control

The paper develops a theoretical framework for optimal metabolic flux maintenance through gene expression control in bacteria, showing that it requires a minimum number of metabolite-regulated transcription factors.

Bifurcation analysis of metabolic pathways: an illustration from yeast glycolysis

The paper develops new methods for bifurcation analysis of metabolic pathways, applying them to yeast glycolysis to explore steady-state behavior and bistability.