Effectiveness of CRISPR-Cas in Sensitizing Bacterial Populations with Plasmid-Encoded Antimicrobial Resistance
Johannes Kippnich, Fabienne Benz, Hildegard Uecker, Franz Baumdicker
This study evaluates how CRISPR-Cas plasmids can sensitize bacteria with plasmid-encoded antibiotic resistance to conventional antibiotics, finding that DNA cleaving is effective for low copy numbers and gene silencing for high copy numbers.
Genetics · Sep 23, 2025Peer-reviewedEvolutionary Biology