The type 2 diabetes factor methylglyoxal mediates axon initial segment shortening and neuronal network activity changes
Ryan B. Griggs, Duc V.M. Nguyen, Leonid M. Yermakov, Jeneane M. Jaber, Jennae N. Shelby, Josef K. Steinbrunner, John A. Miller, Carlos E. Gonzalez-Islas, Peter Wenner, Keiichiro Susuki
This study shows that methylglyoxal, a metabolite of glucose, reduces axon initial segment length and modulates neuronal network activity in type 2 diabetic mice.
eNeuro · Sep 1, 2021Peer-reviewedNeuroscience