Vast population genetic diversity underlies the treatment dynamics of ETV6-RUNX1 ALL
Veronica Gonzalez-Pena, Matthew MacKay, Iwijn De Vlaminck, John Easton, Charles Gawad
The paper uses single-cell sequencing to reveal extensive genetic diversity in ETV6-RUNX1 ALL, showing APOBEC mutagenesis contributes to disease development and chemotherapy response variability.
bioRxiv · Mar 16, 2017 · PreprintCancer Biology