Charles Gawad

The paper uses single-cell sequencing to uncover hidden genetic diversity in pediatric ALL that is not detected by bulk sequencing, identifying treatment-resistant clones and their associated mutations.

The paper identifies differences in mtDNA mutation accumulation and selective pressures in pediatric leukemias using bulk and single-cell sequencing, linking these to functional heterogeneity among leukemic cells.

This study introduces PTA, a single-cell amplification technique that produces nearly complete bacterial genomes and improves viral and gene cluster recovery compared to standard methods.

This study uses ResolveOME to analyze genomic and transcriptomic data in individual cells, revealing mutations and gene expression changes linked to drug resistance and oncogenic mechanisms.

This paper introduces PTA, a new WGA method that improves variant calling accuracy in single cells, enabling studies of genetic diversity and CRISPR off-target effects.

The paper introduces PTA for single-cell DNA sequencing and SCAN2 to detect somatic SNVs and indels in single neurons, finding age-related increases in both with indels having greater functional impact.

The paper uses single-cell sequencing to reveal extensive genetic diversity in ETV6-RUNX1 ALL, showing APOBEC mutagenesis contributes to disease development and chemotherapy response variability.