Role of the CTCF Binding Site in Human T-Cell Leukemia Virus-1 Pathogenesis
Ancy Joseph, Xiaogang Cheng, John Harding, Jacob Al-Saleem, Patrick A. Green, Malachi Griffith, Deborah V. Novack, Daniel A. Rauch, Lee Ratner
This study shows that the CTCF binding site in HTLV-1 regulates viral pathogenesis by affecting proviral load, Tax expression, and T-cell activation in humanized mice.
PLoS Pathogens · Jun 3, 2025Peer-reviewedMicrobiology