Deep Learning of Representations for Transcriptomics-based Phenotype Prediction
Aaron M. Smith, Jonathan R. Walsh, John Long, Craig B. Davis, Peter V. Henstock, Martin R. Hodge, Mateusz Maciejewski, Xinmeng Jasmine Mu, Stephen Ra, Shanrong Zhao, Daniel Ziemek, Charles K. Fisher
The paper evaluates representation learning techniques for transcriptomics-based phenotype prediction using public data and finds that l2-regularized regression on centered log-ratio transformed abundances performs best.
bioRxiv · Mar 15, 2019 · PreprintBioinformatics