Xinmeng Jasmine Mu

The paper identifies SLK as a cancer-specific co-regulator of c-Myc using photoproximity labeling, showing it stabilizes c-Myc and drives tumorigenesis through splicing changes.

The paper shows that inhibiting KAT6/KAT7 enhances Menin inhibitor efficacy and overcomes resistance in MLL-FP leukemia.

This study identifies 40 circulating proteins associated with cancer risk using MR and colocalization, highlighting potential therapeutic targets and adverse effects of protein-altering interventions.

The paper evaluates representation learning techniques for transcriptomics-based phenotype prediction using public data and finds that l2-regularized regression on centered log-ratio transformed abundances performs best.

The paper identifies ATM and PALB2 as CRC risk genes through germline mutation analysis and highlights homologous recombination deficiency in CRC tumors.