Timing antigenic escape in multiple myeloma treated with T-cell redirecting immunotherapies
Marios Papadimitriou, Sungwoo Ahn, Benjamin T. Diamond, Holly Lee, John McIntyre, Marietta S. Truger, Michael A. Durante, Bachisio Ziccheddu, Ola Landgren, Leo Rasche, Nizar Jacques Bahlis, Paola E. Neri, Francesco Maura
The paper shows that genomic antigen escape mechanisms in multiple myeloma occur during CAR-T/TCE treatment, not pre-existing, and emerge after one year of therapy.
bioRxiv · May 22, 2024 · PreprintGenomics