Author

Leo Rasche

University of WürzburgORCID 0000-0002-9536-9649Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Assay:flow cytometry· 1 Assay:scRNA-seq· 1 Approach:statistical model· 1 Research Focus:variant calling· 1

Frequent Co-Authors

Angela RiedeliD· 1 shared Angelika Wolf· 1 shared Annika Hofmann· 1 shared Arpa AintablianiD· 1 shared Bachisio ZicchedduiD· 1 shared Benedict Engel· 1 shared Benjamin T. DiamondiD· 1 shared Cornelia VogtiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperCancer Biology

Angela RiedelORCID

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2 papers

Recent·Most cited

Profound CD4+ T-Cell Reprogramming by Melphalan-Driven Oxidative Stress in High-Risk Multiple Myeloma

Mara John, Nazia Afrin, Xiang Zhou, Emilia Stanojkovska, Hanna Fischer, Maximilian J Krämer, Werner Schmitz, Lars Grundheber, Moutaz Helal, Arpa Aintablian, Silvia Nerreter, Cornelia Vogt, Shilpa Kurian, Angelika Wolf, Sarah Wiethe, , Angela Riedel

This study shows that melphalan treatment causes oxidative stress in T cells, reducing CD4+ naive T cells in high-risk multiple myeloma patients.

bioRxiv · Jun 11, 2026 · PreprintCancer Biology

Timing antigenic escape in multiple myeloma treated with T-cell redirecting immunotherapies

Marios Papadimitriou, Sungwoo Ahn, Benjamin T. Diamond, Holly Lee, John McIntyre, Marietta S. Truger, Michael A. Durante, Bachisio Ziccheddu, Ola Landgren, Leo Rasche, Nizar Jacques Bahlis, Paola E. Neri, Francesco Maura

The paper shows that genomic antigen escape mechanisms in multiple myeloma occur during CAR-T/TCE treatment, not pre-existing, and emerge after one year of therapy.

bioRxiv · May 22, 2024 · PreprintGenomics