Self organisation of invasive breast cancer driven by the interplay of active and passive nematic dynamics
Pablo Gottheil, Saraswat Bhattacharyya, Philip Friedrich, Kilian Roth, Mario Merkel, Kolya Lettl, Kudor Harb, Salvador Rivera-Moreno, Assal Daneshgar, Jonas Wieland, Bahriye Aktas, Jens-Uwe Blohmer, Hans Kubitschke, Anne-Sophie Wegscheider, Christine Sers, , Josef Alfons Käs
The paper shows invasive breast cancer clusters self-organize through active nematic dynamics interacting with passive ECM nematic structures, with higher activity linked to worse patient outcomes.
Physical Review X · Oct 15, 2026Peer-reviewedBiophysics