The unexpected dual role of S100A9 amyloid protein on neurodegeneration in progressive multiple sclerosis motor cortex
Jonathan Pansieri, Jonathan Atwood, Marco Pisa, Richard L. Yates, Gabriele Carmine DeLuca
This study identifies a dual role of S100A9 in progressive multiple sclerosis, showing it drives neurotoxicity extracellularly but may protect neurons intracellularly in microglia.
bioRxiv · Nov 21, 2025 · PreprintNeuroscience