NeurosciencebioRxivPreprint
The unexpected dual role of S100A9 amyloid protein on neurodegeneration in progressive multiple sclerosis motor cortex
Jonathan Pansieri, Jonathan Atwood, Marco Pisa…·Gabriele Carmine DeLuca
This study identifies a dual role of S100A9 in progressive multiple sclerosis, showing it drives neurotoxicity extracellularly but may protect neurons intracellularly in microglia.
DOI 10.1101/2025.11.21.689707