Hydration and hydrolysis define antibiotic resistance conferred by macrolide esterases
Emma T. R. Kelly, Iryna Myziuk, Mark Hemmings, Zahi Mulla, Jonathan Blanchet, Antonio C. Ruzzini, Albert Marinus Berghuis
This study characterizes four Est-type macrolide esterases, revealing structural and functional insights into their substrate specificity and resistance mechanisms.
Proceedings of the National Academy of Sciences · Jul 15, 2026Peer-reviewedBiochemistry