Acute or chronic depletion of macrophages in the dorsal root ganglia induces neuropathic pain after unilateral cervical spinal cord injury in rats
Soha J. Chhaya, Jonathan Houston Richards, Grace A. Giddings, Megan Ryan Detloff
This study investigates the role of CCL2-CCR2 signaling in macrophage recruitment and persistence in the dorsal root ganglia after spinal cord injury, showing that CCR2 antagonism transiently reduces pain but does not prevent long-term hypersensitivity.
bioRxiv · Aug 11, 2023 · PreprintNeuroscience