Lupus Immune Complexes Drive Distinct Pro-Inflammatory Monocyte and Macrophage Populations Independent of Type I Interferon
Lais Osmani, Min Sun Shin, Sang Jin Lee, Helen Q. Cai, Won Jae Seong, Hyoungsu Kim, Jongjin Yoo, M. J. Kim, William Bracamonte, Mario Felix, Jong Gyun Ahn, Hong‐Jai Park, Junghee J. Shin, Serhan Ünlü, Jennefer Par‐Young, , Insoo Kang
This study identifies pro-inflammatory monocyte and macrophage subsets driven by lupus immune complexes, independent of type I interferon signaling, using scRNA-seq and proteomic analysis.
bioRxiv · Apr 24, 2026 · PreprintImmunology