An engineered chromatin protein with enhanced preferential binding of H3K27me3 over H3K9me3
Kierra A. Franklin, J. Harrison Priode, Arefeh Abbasi, Ivan Kordic, Joongho Sohn, Paige Steppe, Ahmet F. Coskun, Esther W. Gomez, Karmella Ann Haynes
The paper describes engineered chromatin-binding proteins that preferentially bind H3K27me3 over H3K9me3, validated using a novel CHIA assay.
bioRxiv · Oct 2, 2024 · PreprintSynthetic Biology