High cell-type specificity of eQTLs revealed by single-nucleus analyses of brain and blood
Martijn Vochteloo, Anoek Kooijmans, Joost Bakker, Roy Oelen, Jelmer Niewold, Dan Kaptijn, Marc Jan Bonder, Monique G.P. van der Wijst, Yunfeng Huang, Julien Bryois, Ellen A. Tsai, Lude Franke, Harm-Jan Westra
The paper identifies highly cell-type-specific eQTLs using snRNA-seq data from brain and blood, showing that bulk analyses overestimate eQTL agreement.
bioRxiv · Nov 26, 2025 · PreprintGenetics