Chronic replication stress-mediated genomic instability disrupts placenta development in mice
Mumingjiang Munisha, Rui Huang, Jordan Khan, John C. Schimenti
This study shows that replication stress from MCM2-7 mutations impairs placenta development in mice by reducing junctional zone proliferation and stemness, leading to poor embryo viability.
PLoS Genetics · Apr 13, 2026Peer-reviewedDevelopmental Biology