Tahoe-100M: A Giga-Scale Single-Cell Perturbation Atlas for Context-Dependent Gene Function and Cellular Modeling
Jesse M. Zhang, Airol A. Ubas, Richard de Borja, Valentine Svensson, Nicole Thomas, Neha Thakar, Ian K. Lai, Aidan F. Winters, Umair Khan, Matthew G. Jones, John D. Thompson, Vuong Tran, Joseph Pangallo, Efthymia Papalexi, Ajay Sapre, , Johnny X. Yu
A 100-million-cell atlas: 50 cancer lines pooled as spheroid villages, treated with 379 drugs at several doses, profiled by combinatorial-barcoding scRNA-seq and embedded with a 10-dimensional scVI model.
bioRxiv · Feb 20, 2025 · PreprintGenomics✦ In-depth digest