Transfer RNA genes experience exceptionally elevated mutation rates
Bryan P. Thornlow, Josh Hough, Jacquelyn M. Roger, Henry Z. Gong, Todd M. Lowe, Russell B Corbett-Detig
The paper shows tRNA genes have much higher mutation rates than the genome average, driven by transcription-associated mutagenesis and purifying selection.
Proceedings of the National Academy of Sciences · Aug 20, 2018Peer-reviewedBioinformatics