Human-dose equivalent 5-fluorouracil triggers a pathophysiological cascade of neuroinflammation, cortical remodeling, and behavioural disruption in Wistar rats.
Olakunle J. Onaolapo, Anthony Tope Olofinnade, Akinsanmi Festus Akinsehinwa, Joshua Ajao, Adejoke Y. Onaolapo
This study shows that 5-fluorouracil causes dose-dependent neurotoxicity in rat cerebral cortex, including behavioral deficits, oxidative stress, neuroinflammation, and histological changes.
bioRxiv · Sep 15, 2025 · PreprintNeuroscience