PERK modulation, with GSK2606414, Sephin1 or salubrinal, failed to produce therapeutic benefits in the SOD1G93A mouse model of ALS
Fernando G. Vieira, Valerie R. Tassinari, Joshua D. Kidd, Andrew Moreno, Kenneth Thompson, Steven Perrin, Alan Gill, Theo Hatzipetros
This study evaluates three PERK modulators in an ALS mouse model and finds they do not provide therapeutic benefits, with some effects possibly mediated through PERK-independent mechanisms.
PLoS ONE · Feb 15, 2024Peer-reviewedNeuroscience