Voxelotor (Oxbryta) Binds Multiple Hemoglobin Sites and Influences Protein Structure
Michael de la Cueva Tamanaha, Esmeralda Flores Cabrera, Joshua Sargeant, Paul David Gershon, Premila P. Samuel, Melanie J. Cocco
This paper investigates Voxelotor's binding sites and structural effects on hemoglobin using NMR and mass spectrometry, revealing heterogeneous binding and potential implications for drug design.
bioRxiv · May 12, 2025 · PreprintBiophysics