A deep learning framework for high-throughput mechanism-driven phenotype compound screening
Thai-Hoang Pham, Yue Qiu, Jucheng Zeng, Lei Xie, Ping Zhang
This paper introduces DeepCE, a deep learning framework for chemical-induced gene expression prediction and compound screening, showing improved performance over existing methods and demonstrating its application to COVID-19 drug repurposing.
Nature Machine Intelligence · Feb 1, 2021Peer-reviewedBioinformatics