Near, far, wherever you are: Phenotype-related variation in pharmacogenomic effect sizes across the psychiatric drug literature.
Siobhan K. Lock, Djenifer B. Kappel, Jude Hutton, Emily Simmonds, Sophie E. Legge, Michael C. O’Donovan, Antonio F. Pardiñas
This study quantifies pharmacogenomic effect sizes for psychiatric drugs, finding larger effects for proximal outcomes like bioavailability than distal outcomes like efficacy and toxicity.
Frontiers in Pharmacology · Jan 16, 2026Peer-reviewedGenetic & Genomic Medicine