Author

Djenifer B. Kappel

Cardiff UniversityORCID 0000-0002-2906-5911Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:statistical model· 3 Research Focus:benchmarking· 1 Research Focus:GWAS / association mapping· 1 Assay:GWAS summary statistics· 1 Research Focus:variant effect prediction· 1 Assay:whole-exome sequencing· 1

Frequent Co-Authors

Antonio F. PardiñasiD· 3 shared Michael C. O’DonovaniD· 3 shared James WaltersiD· 2 shared Michael John OweniD· 2 shared Adrian King· 1 shared Eilidh FenneriD· 1 shared Elliott ReesiD· 1 shared Emily SimmondsiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersGenetic & Genomic Medicine

Antonio F. PardiñasORCID

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3 papers

Recent·Most cited

Genetic & Genomic MedicineFrontiers in PharmacologyPeer-reviewedJan 16, 2026

Near, far, wherever you are: Phenotype-related variation in pharmacogenomic effect sizes across the psychiatric drug literature.

Siobhan K. Lock, Djenifer B. Kappel, Jude Hutton…·Antonio F. Pardiñas

This study quantifies pharmacogenomic effect sizes for psychiatric drugs, finding larger effects for proximal outcomes like bioavailability than distal outcomes like efficacy and toxicity.

DOI 10.3389/fphar.2025.1719761

humanstatistical model

Genetic & Genomic MedicineThe Lancet PsychiatryPeer-reviewedMay 5, 2025

Genetic liability to physical health conditions influences comorbidities in individuals with severe mental illness

Djenifer B. Kappel, Sophie E. Smart, Michael John Owen…·James Walters

The paper examines how genetic risk for physical health conditions affects comorbidities in individuals with severe mental illness, finding stronger genetic associations than psychiatric risk factors.

9 citationstop 4%

humanGWAS summary statistics

Genetic & Genomic MedicineEuropean NeuropsychopharmacologyPeer-reviewedFeb 3, 2024

Rare Variants in Pharmacogenes Influence Clozapine Metabolism in Individuals with Schizophrenia

Djenifer B. Kappel, Elliott Rees, Eilidh Fenner…·Antonio F. Pardiñas

This study identifies rare genetic variants in pharmacogenes that influence clozapine metabolism in schizophrenia patients, with CYP1A2 variants showing the strongest effect.

10 citations

humanwhole-exome sequencing