A Synergistic Desmin-SPARC Axis Regulates Cardiac Stem Cell Differentiation and Promotes Cardiomyogenesis through Autocrine Regulation
Lucia M. Leitner, Martina Schultheis, Franziska Hofstetter, Claudia Rudolf, Valeria Kizner, Kerstin Fiedler, Marie‐Therese Konrad, Julia Höbaus, Marco Genini, Julia Kober, Elisabeth Ableitner, Teresa Gmaschitz, Diana Walder, Georg Weitzer
The paper shows that desmin induces SPARC secretion in cardiac stem cells, promoting cardiomyogenesis through autocrine signaling and enhancing myocardial transcription factor expression.
bioRxiv · Mar 28, 2024 · PreprintDevelopmental Biology