Controlled and Selective Photo-oxidation of Amyloid-β Fibrils by Oligomeric p-Phenylene Ethynylenes
Adeline M. Fanni, Daniel Okoye, Florencia A. Monge, Julia Hammond, Fahimeh Maghsoodi, Tye D. Martin, Gabriella Brinkley, M. Lisa Phipps, Deborah G. Evans, Jennifer S. Martinez, David G. Whitten, Eva Y. Chi
This study demonstrates that oligo-p-phenylene ethynylene compounds selectively oxidize amyloid-beta fibrils without affecting monomers, reducing toxicity and improving the selectivity of photodynamic therapy.
ACS Applied Materials & Interfaces · Mar 28, 2022Peer-reviewedNeuroscience