Distances and charges along the Orai1 nexus-TM3 interface control STIM1-binding and pore opening
Julia Söllner, Magdalena Prantl, Hadil Najjar, Veronika Aichner, Ana Marija Suta, Yuliia Nazarenko, Dajana Zoric, Selina Harant, Maximilian Fröhlich, Tamara Radiskovic, Diana Thallinger, Christopher Mairhofer, William Nzegge, Sarah Weiß, Heinrich Krobath, , Isabella Derler
The paper investigates how distances and charges at the Orai1 nexus-TM3 interface influence STIM1-binding and pore opening in the CRAC channel.
Cell Reports · Feb 1, 2026Peer-reviewedBiophysics