The C-terminus and Third Cytoplasmic Loop Cooperatively Activate Mouse Melanopsin Phototransduction
Juan C. Valdez‐Lopez, Stephen T. Petr, Matthew P. Donohue, Robin J. Bailey, Meheret Gebreeziabher, Evan G. Cameron, Julia Wolf, Veronika A. Szalai, Phyllis R. Robinson
This study identifies the C-terminus and third cytoplasmic loop of mouse melanopsin as critical for activation, showing their proximity and role in G-protein coupling through phosphorylation and ionic interactions.
Biophysical Journal · Jun 23, 2020Peer-reviewedNeuroscience