An anti-ACVR1 antibody exacerbates heterotopic ossification by fibro/adipogenic progenitors in fibrodysplasia ossificans progressiva mice
John B. Lees-Shepard, Sean J. Stoessel, Julian Chandler, Keith Bouchard, Patricia Bento, Lorraine N. Apuzzo, Parvathi M. Devarakonda, Jeffrey W. Hunter, David J. Goldhamer
This study shows that an anti-ACVR1 antibody worsens heterotopic ossification in FOP mouse models by altering fibro/adipogenic progenitor behavior.
Journal of Clinical Investigation · May 3, 2022Peer-reviewedDevelopmental Biology