Early spatial and contextual coding deficits in hippocampal CA1 precede performance decline in an Alzheimer's disease model.
Yimei Li, Ann Go, Hualong Zhang, Robertas Aleksynas, Juliana Kim, Mingyang Gao, Seigfred V. Prado, Magdalena Sastre, Simon R. Schultz
This study identifies early hippocampal coding deficits in 5xFAD mice before behavioral decline, showing impaired contextual representations and shifts in encoding strategies.
Advanced Science · Sep 9, 2026Peer-reviewedNeuroscience