Histone deacetylase inhibition mitigates cognitive deficits and astrocyte dysfunction induced by Ab oligomers
Juliana Morgado, Luan Pereira Diniz, Ana Paula Bérgamo Araújo, Leticia Maria da Silva Antônio, Hannah P. Mota-Araujo, Pedro de Sena Murteira Pinheiro, Fernanda Savacini Sagrillo, Gabriele Vargas, Sergio Teixeira Ferreira, Cláudia Pinto Figueiredo, Carlos Alberto Manssour Fraga, Flávia Carvalho Alcântara Gomes
This study shows that LASSBio-1911, an iHDAC6 inhibitor, improves cognitive function and astrocyte function in AβO-infused mice.
bioRxiv · Oct 25, 2023 · PreprintNeuroscience