Tumor clone dynamics in gastro-esophageal cancer organoids reveal a non-genetic memory of neoadjuvant chemotherapy via downregulation of NFκB signaling
Thi Tuong Vi Dang, Tim Schmäche, Dmitrii Severinov, Vivian Mittné, Juliane Fohgrub, Franziska Baenke, Daniel E. Stange, Anna R. Poetsch
The paper investigates tumor clone dynamics in gastro-esophageal cancer organoids after neoadjuvant chemotherapy, finding that NFκB signaling downregulation contributes to non-genetic transcriptional reprogramming.
bioRxiv · Jul 29, 2025 · PreprintCancer Biology