Tumor clone dynamics in gastro-esophageal cancer organoids reveal a non-genetic memory of neoadjuvant chemotherapy via downregulation of NFκB signaling
Thi Tuong Vi Dang, Tim Schmäche, Dmitrii Severinov…·Anna R. Poetsch
The paper investigates tumor clone dynamics in gastro-esophageal cancer organoids after neoadjuvant chemotherapy, finding that NFκB signaling downregulation contributes to non-genetic transcriptional reprogramming.