Bacterial type 1A topoisomerases maintain the stability of the genome by preventing and dealing with R-loop-and nucleotide excision repair-dependent topological stress.
Julien Brochu, Émilie Vlachos-Breton, Marc Drolet
The paper shows that type 1A topoisomerases prevent and resolve topological stress from R-loops and nucleotide excision repair in E. coli by providing relaxase and decatenase activities.
bioRxiv · Jul 10, 2021 · PreprintMolecular Biology