Immunoglobulins are rapidly internalized by neurons after CNS injury and cleared through lysosomal degradation
Adrian Castellanos-Molina, Ana Boisvert, Juliette Ferry, Dominic Bélanger, Audrée Laroche, Romain Menet, Frederique Crepeau, Martine Lessard, Nadia Fortin, Nicolas Vallières, Isabelle Allaeys, Nicolas Bertrand, Ayman ElAli, Éric Boilard, Steve Lacroix
This study shows that neurons internalize and clear immunoglobulins after CNS injury through lysosomal degradation, and inhibiting lysosomal proteases increases IgG retention without affecting locomotor recovery.
bioRxiv · Jul 21, 2026 · PreprintNeuroscience