Dietary selenium deficiency drives sex-specific circadian disturbance through redox imbalance and causes early systolic dysfunction in mice
Xuanxuan Guo, Ferdy Lambregtse, Lotte Geerlings, Jumo Zhu, Sietske N. Zijlstra, Anna M. Feringa, Elisabeth M. Schouten, Herman H.W. Silljé, Lutz Schomburg, Peter van der Meer, Nils Bömer
This study shows that selenium deficiency in mice causes early systolic dysfunction and molecular changes linked to redox imbalance and circadian disruption, with sex-specific effects.
bioRxiv · Sep 29, 2026 · PreprintMolecular Biology