Cumulus cells mediate the protective effect of the marine carotenoid fucoxanthin against postovulatory oocyte aging via NRF2 signaling
Chansik Oh, Soon-Tae Kwon, Hyuk Nam Kwon, Jung-Hee Woo, Jeong Eun Lee, Sangyong Jung
This study shows that fucoxanthin protects mouse oocytes from postovulatory aging by activating NRF2 in cumulus cells, improving mitochondrial function and reducing oxidative stress.
bioRxiv · Nov 2, 2026 · PreprintCell Biology