Machine learning-based framework for predicting human infection potential of coronavirus associated with tri-amino acid motifs, KIQ and LEP in spike protein
Narathit Chanraeng, Junwen Guo, Tarapong Srisongkram, Yothin Hinwan, Peter Fransson, Henrik Sjödin, Yoshiharu Matsuura, Hans Jørgen Overgaard, Watcharapong Panthong, Tipaya Ekalaksananan, Chamsai Pientong, Supranee Phanthanawiboon
This paper develops a machine learning framework to predict human infection potential of coronaviruses using spike protein sequences, identifying motifs KIQ and LEP associated with human infection.
bioRxiv · Feb 16, 2026 · PreprintBioinformatics