Yoshiharu Matsuura

This paper develops a stable reporter platform for human rhinovirus and other enteroviruses by optimizing gene insertion and stability.

This paper develops a HiBiT-expressing recombinant rat hepacivirus that can infect both in vitro and in vivo, enabling quantitative antiviral screening and pathogenicity studies.

The paper develops a GFP-based reporter to measure 3C protease activity in picornaviruses, showing it works across diverse viral strains and identifies amino acid effects on enzyme activity.

This study identifies new RNA viruses in invasive camelids in Australia, revealing convergent evolution of upstream ORFs across divergent picornaviruses.

This paper develops a machine learning framework to predict human infection potential of coronaviruses using spike protein sequences, identifying motifs KIQ and LEP associated with human infection.

This study identifies claudin-3 as an entry factor for rat hepacivirus, showing host-specificity determined by two amino acids in extracellular loop 1.

This study finds that BCR repertoire diversity, not TCR diversity, correlates with favorable outcomes in COVID-19 patients.

This study identifies that HCV infection promotes PA28γ acetylation and heptamerization, enhancing proteasomal degradation of RNF2 and leading to HOX gene expression.

The paper introduces an epoxidized graphene grid (EG-grid) that improves particle density and orientation in cryoEM, enabling high-resolution structural analysis with fewer micrographs.

The paper presents nine alpaca nanobodies that recognize conserved hidden epitopes on SARS-CoV-2 spike proteins across variants and maintain neutralizing activity against escape mutations.