Disruption of Marrow Microenvironments in Chronic Lymphocytic Leukemia by High-Resolution Synchrotron Micro-Computed Tomography
In Kyu Lee, Yoshihiro Obata, Anthony D. Pomicter, Justin A. Williams, Bejal Kikani, Christopher Edward Jensen, Douglas Weston Sborov, Deborah Marie Stephens, Claire Acevedo
This study uses synchrotron micro-CT to quantify microstructural changes in CLL marrow, finding reduced lacuna density and increased adipose surface area linked to disease burden and therapy response.
bioRxiv · Oct 20, 2025 · PreprintPhysiology