Modulation of mutant KrasG12D-driven lung tumorigenesis in vivo by gain or loss of PCDH7 function
X. Zhou, B. M. Evers, M. S. Padanad, J. A. Richardson, E. Stein, J. Zhu, R. E. Hammer, K. A. O'Donnell
This study shows PCDH7 promotes lung cancer growth in mice by accelerating KrasG12D-driven tumorigenesis and enhancing MAPK pathway activation, while its loss reduces tumor development and extends survival.
bioRxiv · Jun 8, 2018Cancer Biology