K. C. Sivakumar

Targeting Galectin-3 C-epitope oligomers associated maladaptive mechanotransductive signaling in pressure-overload induced left ventricular cardiac hypertrophy

This study identifies Gal-3 C-epitope oligomers as pathogenic in cardiac hypertrophy and shows that Amalaki Rasayana and gallic acid reduce their levels and mitigate adverse effects.

Galectin-3 C-epitope, ANP, PPIA, and albumin function as drug-responsive panel biomarkers and therapeutic targets in aging and pressure overload-induced cardiac hypertrophy

The paper identifies a biomarker panel responsive to treatment in cardiac hypertrophy and aging, showing that galectin-3 C-epitope, ANP, PPIA, and albumin levels decrease with therapeutic intervention in rat models and human patients.