A class of GATA3 mutation reprograms the breast cancertranscriptional network through gain and loss of function
M. Takaku, S. A. Grimm, J. D. Roberts, K. Chrysovergis, B. D. Bennett, P. Myers, L. Perera, C. J. Tucker, C. M. Perou, P. A. Wade
This study shows that some GATA3 mutations in breast cancer cause both loss and gain of function, altering the transcriptional network.
bioRxiv · Oct 16, 2017Cell Biology