How a Formate Dehydrogenase Responds to Oxygen: Unexpected O2 Insensitivity of an Enzyme Harboring Tungstopterin, Selenocysteine, and Clusters.
J. E. Graham, D. Niks, G. M. Zane, Q. Gui, K. Hom, R. Hille, J. D. Wall, C. S. Raman
This paper characterizes an O2-insensitive FDH2 from Desulfovibrio vulgaris that couples formate oxidation to CO2 production without superoxide release, revealing redox bifurcation and implications for biofuel cell design.
bioRxiv · Jan 18, 2022Biochemistry