HTLV-1 reverse transcriptase homology model provides structural basis for sensitivity to existing nucleoside/nucleotide reverse transcriptase inhibitors
J. S. O'Donnell, N. Tardiota, N. Jaberolansar, J. A. Lackenby, K. J. Chappell
This study uses homology modeling to show that NRTIs bind HTLV-1 reverse transcriptase with similar affinity to HIV-1, supporting their potential use in HTLV-1 treatment.
bioRxiv · May 25, 2023Pharmacology & Toxicology